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Knee pain is a prevalent and growing public health concern, particularly among adults, making it one of the most frequent reasons for primary care consultations. Research indicates that nearly 25% of Americans over the age of 55 experience chronic knee pain, with osteoarthritis (OA) being the leading cause (Hunter et al., 2022). This condition not only contributes to reduced mobility and disability but also imposes significant financial burdens, with knee OA-related medical costs surpassing $80 billion annually (Shema-Shiratzky et al., 2023).
As the aging population continues to rise, primary care providers play a critical role in early diagnosis, risk assessment, and effective management of knee pain. While osteoarthritis accounts for approximately 13.8% of cases, other contributing factors include previous knee injuries, inflammatory conditions, and psychosocial influences (Bedenbaugh et al., 2021; Sugai et al., 2018). Risk factors such as age, obesity, and prior trauma can negatively impact treatment outcomes, making a comprehensive and multidisciplinary approach essential for optimal patient care (Collier et al., 2023).
In summary, knee pain remains a prevalent complaint in the adult population presented to primary care physicians. With a multifactorial nature, underlying causes predominantly include osteoarthritis and previous injuries alongside psychological factors affecting pain perception. Addressing the growing burden of knee pain will require enhanced awareness and innovative treatment strategies within primary care.
Key differentials to consider include
Cause | Key Features/Description | Primary Care Considerations |
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Osteoarthritis | Degenerative joint disease; pain worsens with activity; common in older adults. |
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Rheumatoid Arthritis | Autoimmune inflammatory disorder; symmetrical joint involvement, swelling, warmth, morning stiffness. |
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Meniscal Tears | Injury to knee cartilage (often twisting motion). Symptoms include locking, catching, joint line tenderness. |
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Ligament Injuries | ACL, PCL, MCL, or LCL damage from pivoting/trauma. Presents with instability, swelling. |
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Patellofemoral Pain Syndrome | “Runner’s knee.” Anterior knee pain worsened by stair climbing, prolonged sitting, malalignment. |
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Patellar Tendinitis | “Jumper’s knee.” Overuse inflammation of patellar tendon, localized below kneecap. |
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Bursitis | Inflammation of fluid-filled sacs (prepatellar, pes anserine). Localized swelling, tenderness. |
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Gout / Pseudogout | Crystal-induced arthropathies; acute severe pain, swelling, redness. Gout (urate↑), Pseudogout (CPPD crystals). |
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Septic Arthritis | Infection within the joint. Severe pain, redness, swelling, fever, inability to bear weight. |
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Referred Pain | Pain originating from hip or lumbar spine pathology but felt in the knee. |
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Almeida, B., Capela, A., Pinto, J., Santos, V., Silva, C., & Rosa, M. (2019). Relationship between the perceived social support and catastrophization in individuals with chronic knee pain. Brazilian Journal of Pain, 2(1). https://doi.org/10.5935/2595-0118.20190011
Bedenbaugh, A., Bonafede, M., Marchlewicz, E., Lee, V., & Tambiah, J. (2021). Real-world health care resource utilization and costs among US patients with knee osteoarthritis compared with controls. ClinicoEconomics and Outcomes Research, 13, 421-435. https://doi.org/10.2147/ceor.s302289
Collier, T., Hughes, T., Chester, R., Callaghan, M., & Selfe, J. (2023). Prognostic factors associated with changes in knee pain outcomes, identified from initial primary care consultation data: A systematic literature review. Annals of Medicine, 55(1), 401-418. https://doi.org/10.1080/07853890.2023.2165706
Hunter, C., Deer, T., Jones, M., Chien, G., D’Souza, R., Davis, T., … & Strand, N. (2022). Consensus guidelines on interventional therapies for knee pain (STEP guidelines) from the American Society of Pain and Neuroscience. Journal of Pain Research, 15, 2683-2745. https://doi.org/10.2147/jpr.s370469
Kelly, T., Pazzol, M., & Darabad, R. (2023). Peripheral nerve stimulation in chronic knee pain: A case series. Cureus. https://doi.org/10.7759/cureus.50127
Shema-Shiratzky, S., Mor, A., & Elbaz, A. (2023). Untitled. Journal of Musculoskeletal Disorders and Treatment, 9(1). https://doi.org/10.23937/2572-3243/9/1
Sugai, K., Takeda‐Imai, F., Michikawa, T., Nakamura, T., Takebayashi, T., & Nishiwaki, Y. (2018). Association between knee pain, impaired function, and development of depressive symptoms. Journal of the American Geriatrics Society, 66(3), 570-576. https://doi.org/10.1111/jgs.15259
Tafler, L., Ovshaev, S., Ayon, S., & Luu, A. (2023). A novel knee traction technique to treat chronic knee pain. Cureus. https://doi.org/10.7759/cureus.43526