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For women experiencing menopausal symptoms who cannot or choose not to use hormonal replacement therapy (HRT), there are several effective non-hormonal medications and treatment options available. Here are the key alternatives:
| Agent | Type/Category | Indications/Benefits | Considerations |
|---|---|---|---|
| Selective Serotonin Reuptake Inhibitors (SSRIs) | Antidepressant | Useful for vasomotor symptoms (e.g., hot flashes, night sweats). | Common options include Paroxetine and Escitalopram; may cause nausea or sexual dysfunction. |
| Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) | Antidepressant | Can help reduce hot flashes and improve mood. | Common options include Venlafaxine; may cause increased blood pressure or insomnia. |
| Gabapentin | Anticonvulsant/Neuropathic Pain Agent | Effective in reducing hot flashes, particularly night sweats. | Can cause dizziness, fatigue, or weight gain; dose adjustments may be needed. |
| Clonidine | Alpha-2 Adrenergic Agonist | Can reduce the frequency and severity of hot flashes. | May cause dry mouth, drowsiness, or hypotension; typically less effective than SSRIs/SNRIs. |
| Vaginal Moisturizers and Lubricants | Non-hormonal topical treatment | Helps relieve vaginal dryness and discomfort during intercourse. | Available over-the-counter; no systemic side effects. |
| Cognitive Behavioral Therapy (CBT) | Psychological Therapy | May help with mood swings, sleep disturbances, and hot flashes. | Requires access to a trained therapist; involves regular sessions. |
| Lifestyle Modifications | Non-pharmacological Approach | Regular exercise, stress reduction, and a healthy diet can alleviate symptoms. | Should... |
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